2014 – Measurement, Methods and Mechanisms in Randomized Controlled Trials: The ACTIVE Study

Schedule and Presentations 2014

The 11th annual conference on the application of modern psychometric methods to measurement issues in cognitive aging research will explore measurement, methods, mechanisms, and other critical inference issues for intervention studies using data from the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) cognitive intervention study (1998-2010). Workgroups will address how modern data analysis methods can lead to improved power, precision, and reduction of bias in the evaluation of clinical trials.

The 2014 meeting will be chaired by Richard Jones and Alden Gross, and several investigators from the ACTIVE study will be present to represent the study and participate in workgroups. The focus of this meeting will be on improving measurement and reducing bias in outcome measures for intervention studies to ultimately improve ability to develop interventions to maintain cognitive health.

Data will come from the ACTIVE (Advanced Cognitive Training for Independent and Vital Elderly, 1998-2010) study. ACTIVE is the largest randomized controlled trial of a behavioral cognitive improvement intervention among older adults. Approximately 2,800 persons were randomly assigned to one of four arms, three active treatments and one no-contact control. The cohort was followed at 12 weeks and 1, 2, 3, 5 and 10 years after baseline, randomization and treatment. Results from the 10 follow-up were recently published and showed evidence of maintenance of treatment effects over this extended period of follow-up. Workgroups at this meeting will analyze public use data archived at NACDA/ICPSR.